Artificial Intelligence, and particularly generative AI that produces novel outputs based on user prompts fundamentally impacts science communication. It can assist practitioners in generating content or identifying new ideas and trends, translating and preparing scientific results and publications for different channels and audiences, and enabling interactive exchanges with various user groups. It also comes with pronounced challenges, from errors and “hallucinations” in AI outputs over new digital divides all the way to ethical and legal concerns. The Special Issue brings together cutting-edge research assessing the role of AI in science communication, discussing communication about AI, communication with AI, the impact of AI technologies on the larger science communication ecosystem and potential theoretical and methodological implications.