Many scientists make use of social media and take various approaches to humor in their posts to encourage online public engagement, yet little is known about how publics respond to particular types of online science humor. This study investigates the behavioral effects of the presence of different types of science humor, specifically anthropomorphism, wordplay, and the two combined, shared by a scientist on Twitter. Individuals who experienced higher levels of mirth after exposure to humorous science content were more likely to leave a comment on the social media post. Additionally, individuals' need for cognition moderated the relationship between humor exposure and mirth, as well as the relationship between mirth and leaving a comment. These results and future research are discussed.