Despite scientific consensus that genetically modified (GM) food is safe to eat, the American public remains skeptical. This study (N=73) investigates the proposed role of disgust in driving opposition to GM food, which is debated in extant literature. Using physiological measures of disgust, alongside self-report measures, this study suggests that disgust plays a role in driving skepticism toward GM food, but not other food and health technologies. We further discuss the possible influence of risk sensitivity and perceptions of unnaturalness on attitudes toward novel science.