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From a strategic communication perspective, for any communication to be effective, it must be audience-centered, with content and delivery channels that are relevant to its intended target. When trying to reach culturally specific communities or other groups that are not otherwise connected with science research, it is crucial to partner with community members to co-create content through media that is appealing and culturally competent. This commentary considers some examples including storytelling through ‘fotonovelas’ and radio stories, community drama and serious games.