Advances in 21st century genetic technologies offer new directions for addressing public health and environmental challenges, yet raise important social and ethical questions. Though the need for inclusive deliberation is widely recognized, institutionalized risk definitions, regulation standards, and imaginations of publics pose obstacles to democratic participation and engagement. This paper traces how the problematic precedents set by the 1975 Asilomar Conference emerge in contemporary discussions on CRISPR, and draws from a recent controversy surrounding field trial releases of genetically modified mosquitoes to explicate the ways in which these precedents undermine efforts to engage publics in decisions at the science-policy interface.