The making and tinkering movement has become increasingly mainstream over the past decade, pioneered in part through the popularity of magazines like `Make', events such as Maker Faire and DIY websites including `Instructables'. Science centres and museums have been developing their own ideas, notably the Tinkering Studio at the Exploratorium. In this commentary piece, we reflect on why this movement has a strong appeal for the Life Science Centre in Newcastle upon Tyne and why we are in the process of developing a new making and tinkering space to help us enact our centre's vision to `Enrich lives through science'.