The urgent state of our global environment calls for collective action, which depends in large part on effective science communication for better understanding and awareness. Activities and institutions that provide opportunities to learn about nature all ultimately rely on scientific findings about nature. Although science produces the knowledge and information about nature, for the content to be accessible and meaningful to the general public, it needs to be processed by what I call science content design. This process is similar to the concepts of interpretation in tourism, or aesthetic understanding in alternative science education. This study is a theoretical exploration on the definition and nature of science content design, what constitutes its process, and how the content can be designed. Focusing on the fields of macro-biology, I also discuss the types of biological content generally used in nature-based experiences, and examine model cases of biological content design.