Rapid and significant developments in the science of Autism Spectrum Disorders (ASDs) have provoked serious social and ethical concerns as well as positive influences worldwide. This study created a social agenda containing 21 important issues regarding the relationship between ASDs and society and the development of the science of ASDs. The agenda was constructed with the input of a variety of Japanese people who were provided with scientific ASD information and engaged in discussions regarding ASDs. First, opinions were sought via a questionnaire from the attendees of six science café sessions. Then, additional important issues were put forward by attendees of a larger dialogue session regarding the relationship between ASDs and society, again via a questionnaire. The agenda covered a wide range of issues, including information regarding ASDs, people’s understanding of ASDs, social support, education, the difference between ASD characteristics and individuality, ASD research, diagnosis, and social attitudes.