Movements opposing genetically modified organisms (GMOs) remain one of the most impactful protest movements in recent times, successfully suppressing the widespread global acceptance of GMOs through strategically crafted anti-GMO rhetoric. Yet, inadequate research has focused on the arguments used by GMO-promoting advocates. In this media content analysis study, inspired by the Neo-Aristotelian Method of Rhetorical Criticism (NAMRC), we analyze news articles about GMO technologies gathered from the most-read news portals in Ghana. We identify the rhetorical strategies used by GMO-promoting institutions that are reported in media interactions when the legitimacy of these technologies is questioned. We found that pro-GMO rhetoric focuses on themes of problem-solving technology, defensive advocacy, hope for the future, and scientific evidence to persuade publics. In the media coverage we analyzed, pro-GMO advocates defended both the safety of the technology and the legitimacy of scientific research and agricultural innovation. To ensure that advocacy for genetically modified crops is both responsible and credible, advocates of GMO technologies must strike a balance between conveying enthusiasm for these technologies and exercising caution about their limitations.