This article analyzes the public problem of scientific disinformation in the Brazilian media covering the Covid-19 pandemic. A content analysis of 226 articles addressing disinformation as a problem was conducted in a quality newspaper (“Folha de S. Paulo”), a popular website (Metrópoles) and a science journalism magazine (“Pesquisa Fapesp”). The results suggest that the public debate has focused on spreading fake news during the Pandemic and its negative impact on public health. In addition, two opposing discourses, one populist and the other based on the scientific community and institutional normality, structured the public problem of science and disinformation in Brazil.