The paper highlights the feedback loop between media, politics, foreign influence and science in relation to the adoption of Genetically Modified Organisms (GMOs) in food production in Uganda to demonstrate that socio-cultural considerations are important in the GMO science and technology debates. Based on the science-in-society model, the findings from a content analysis of newspaper articles over a four-year period, supplemented by interviews with scientists, activists from non-governmental organisations, journalists, and Members of Parliament's Science and Technology Committee, the study found that food is a politically thick issue. Both activists and scientists opportunistically use the media, the platforms where the public access and contribute content, to appeal to the politicians to legislate GMOs in their favour, arguing that the activists or the scientists' position is in the `public interest'. Often, such coverage produces a paradox for the public by accelerating uncertainty regarding the science and the products of genetic modification, especially when politicians fail to decide for fear of the political implications of their action as is the case in Uganda.