In an increasingly mediated culture, social institutions such as science, public health, and civic engagement exist within the same modes of discourse as popular media. As a human endeavor, science is also a cultural phenomenon, and there are webs of multidirectional and layered communication that occur between formal science communication, pop science, and, indeed, popular media. For public participants, engagement with science and entertainment may be one in the same. This essay draws from research of transformative works, fan studies, and memetics to examine how the public engages with science and popular media within digital cultures.