This study explores how South African newspaper cartoonists portrayed the novel coronavirus during the initial months of the COVID-19 pandemic. We show how these cartoons respond to the socio-economic and cultural contexts in the country. Our analysis of how cartoonists represent the novel coronavirus explain how they create meaning (and may influence public sentiments) using colour, morphological characteristics and anthropomorphism as visual rhetorical tools. From a total population of 497 COVID-19-related cartoons published in 15 print and online newspapers from 1 January to 31 May 2020, almost a quarter (24%; n=120) included an illustration of the coronavirus. Viruses were typically coloured green or red and attributed with human characteristics (most often evil-looking facial expressions) and with exaggerated, spikey stalks surrounding the virus body. Anthropomorphism was present in more than half of the 120 cartoons where the virus was illustrated (58%; n=70), while fear was the dominant emotional tone of the cartoons. Based on our analysis, we argue that editorial cartoons provide a useful source to help us understand the broader discursive context within which public communication of science operates during a pandemic.