This paper offers an ethnographic account of the editorial response to the COVID-19 outbreak by the Science Media Center Germany. Ethnographic research data was gathered during a 4-week fieldstay in January 2020 which coincided with the first weeks of the COVID-19 outbreak. The findings offer insights into how the editorial staff grappled with the scientific non-knowledge and uncertainty that marked the initial phase of the global COVID-19 outbreak, while simultaneously dealing with acute journalistic demands for expertise.