Fostering interdisciplinary collaboration is critical for addressing complex research problems. At the earliest stages of research ideation and mobilization, we need to create environments that cultivate collective creativity, curiosity and decision making among those with diverse expertise. The fields of design and design thinking offer excellent tools and approaches for promoting rich conversations while simultaneously navigating ambiguity. Here we describe how design strategies can support team science, specifically as loosely formed groups collaboratively brainstorm around intractable problems.