Today, science and politics are in a complex status of reciprocal dependency. Politics is dependent on scientific expertise in order to adequately address highly complex social problems, and science is fundamentally dependent on public funding and on political regulation. Taken together, the diverse interactions, interrelations and interdependencies of science and politics create a heterogenous and complex patchwork — namely, the science-policy interface. The societal relevance for phenomena such as scientific policy advice, science governance or (politically fostered) science communication have been amplified by the developments of digitalisation and now call for new approaches to clarify the ambiguous relationships within the science-policy interface. This special issue aims to provide a platform for researchers to address communication at the intersection of science and politics from different angles. The research presented in the special issue, thus, aims to reduce the contingency of science-policy communication in its various dimensions and looks to spur further investigations into the science-policy interface.