Mediators engage in peer-to-peer conversations with young adults visiting the art and science exhibitions at Science Gallery Dublin. Previous evaluation and anecdotal reports show that the interdisciplinary nature of these conversations fosters self-confidence and interest in academic careers. We used the Most Significant Change methodology to evaluate if working as a Mediator has an impact beyond these domains. The results show that civic engagement, interest in social justice and emotional empathy are domains of significant personal change strongly associated with the development of self-confidence and interpersonal skills.