This paper tries to 1) identify the dominant media frames of science and 2) compare media selection and framing of science-related articles in Croatian daily newspapers during two politically and socioculturally different periods: the late socialism and the (post)transition. The research methodology was based on content and frame analysis which encompassed articles on science in daily press with the highest readership between 1986–1988, and 2006–2008. The main findings indicate changes in the selection of science topics as well as in the representation of individual frames. Changes reflected not only current events in the world of science but also wider social and journalistic values, as well as evaluations of the importance of specific topics.