How will peer to peer infrastructures, and the underlying intersubjective and ethical relational model that is implied by it, affect scientific practice? Are peer-to-peer forms of cooperation, based on open and free input of voluntary contributors, participatory processes of governance, and universal availability of the output, more productive than centralized alternatives? In this short introduction, Michel Bauwens reviews a number of open and free, participatory and commons oriented practices that are emerging in scientific research and practice, but which ultimately point to a more profound epistemological revolution linked to increased participatory consciousness between the scientist and his human, organic and inorganic research material.