The present article investigates public understanding of HIV/AIDS related issues that touch the thought structure of common citizen, among the Indian public. Analysis is based on a representative sample collected from 10 states of India. The authors have also analysed the relative cultural distance at which men and women, as separate groups, could be placed. The relative cultural distance, for each of the selected issues, has been computed and it was found that men, as a group, are closer to scientific thought structure compared to women.