Research systems are increasingly required to be more practically oriented and to address issues which appear more promising in economic and social results, with special reference to trans-disciplinary research fields, such as nanotechnology or ICTs; policy makers show a sharp tendency to establish research priorities and to drive research systems; universities and research institutions are asked to be more transparent and open to dialogue with social actors on contents, impacts, ethical implications and practical applications of scientific and technological research. These transformations affecting both the ways in which science and technology are produced and their relationships with society pose new challenges to European research. All the aspects of research activities are concerned, including the life of the research groups, the approaches to scientific evaluation, the development of European research policies and the interaction between researchers with their social environment. Continuing a reflection started in the last issue of JCOM, Luisa Prista, Evanthia Kalpazidou-Schmidt, Brigida Blasi, Sandra Romagnosi and Miguel Martínez López offered their contribution in identifying some of the key implications and risks which these changes are bringing about, mainly in the perspective of the construction of the European Research Area.